Parasites such as Plasmodium and Toxoplasma possess a vestigial plastid homologous to
the chloroplasts of algae and plants. The plastid (known as the apicoplast; for apicomplexan …

Although many new anti-infectives have been discovered and developed solely using
phenotypic cellular screening and assay optimization, most researchers recognize that …

A major cause of the paucity of new starting points for drug discovery is the lack of
interaction between academia and industry. Much of the global resource in biology is …

The threat of widespread drug resistance to frontline antimalarials has renewed the urgency
for identifying inexpensive chemotherapeutic compounds that are effective against …

Open-access drug discovery provides a substantial resource for diseases primarily affecting
the poor and disadvantaged. The open-access Pathogen Box collection is comprised of …

We report detailed susceptibility profiling of asexual blood stages of the malaria parasite
Plasmodium falciparum to clinical and experimental antimalarials, combined with …

Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a
nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary …

High-throughput phenotypic screening of chemical libraries has resulted in the identification
of thousands of compounds with potent antimalarial activity, although in most cases, the …

Cultured human pathogens may differ significantly from source populations. To investigate
the genetic basis of laboratory adaptation in malaria parasites, clinical Plasmodium …

Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent
drug target due to its bacterial-like ancestry. Numerous parasiticidals have been proposed to …