The discovery of a pathogenic variant in the alpha-synuclein (SNCA) gene in the Contursi
kindred in 1997 indisputably confirmed a genetic cause in a subset of Parkinson's disease …

Abstract Alzheimer's disease (AD), similar to AD-related dementias, is characterized by
impaired/lost neuronal structures and functions due to a long progression of …

Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …

Misfolding and aggregation of amyloid-β (Aβ) peptides are key hallmarks of Alzheimer's
disease (AD). With accumulating evidence suggesting that different Aβ species have varied …

The risk of developing Alzheimer's disease (AD) significantly increases in individuals
carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist …

DNA methylation, the main epigenetic modification regulating gene expression, plays a role
in the pathophysiology of neurodegeneration. Previous evidence indicates that 5′-flanking …

Alzheimer's disease is increasing in prevalence disproportionately to longevity, placing
enormous burden on individuals, families, healthcare systems and the economy …

Alzheimer's disease (AD) is the most common type of dementia and a significant concern to
global public health due to the prevalence of aging populations. Donepezil is one of only a …

The etiology of various neurodegenerative disorders that mainly affect the central nervous
system including (but not limited to) Alzheimer's disease, Parkinson's disease and …

The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β
(Aβ) peptides are generated after proteolytic cleavage. Aβ peptides are the main constituent …