Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Recent studies suggest that a key mechanism whereby the gut microbiome influences
energy balance and glucose homeostasis is through the recruitment of brown and beige …

Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is a soluble lipid-binding
protein that transports phosphatidylcholine (PC) between cellular membranes. To better …

Objective Previous studies have established that deficiency in Nucleotide-binding and
oligomerization domain (NOD)-like receptor family pyrin domain containing 6 (Nlrp6) …

Background The accumulation of ectopic fats is related to metabolic syndromes with insulin
resistance, which is considered as the first hit in obesity-related diseases. However …

Thyroid hormone (TH) action is essential for hepatic lipid synthesis and oxidation. Analysis
of hepatocyte-specific thyroid receptor β1 (TRβ1) knockout mice confirmed a role for TH in …

Objective The nuclear receptor corepressor 1 (NCOR1) and the silencing mediator of
retinoic acid and thyroid hormone (SMRT, also known as NCOR2) play critical and specific …

The vitamin D receptor (VDR) must be relevant to liver lipid metabolism because VDR
deficient mice are protected from hepatosteatosis. Therefore, our objective was to define the …

Background and Aims Obesity‐induced pathogenesis of nonalcoholic fatty liver disease
(NAFLD) and nonalcoholic steatohepatitis (NASH) is associated with increased de novo …