von Willebrand disease

O Seidizadeh, JCJ Eikenboom, CV Denis… - Nature Reviews …, 2024 - nature.com
Abstract von Willebrand disease (VWD) is the most common inherited bleeding disorder.
The disorder is characterized by excessive mucocutaneous bleeding. The most common …

The necessity of repeat testing for von Willebrand disease in adult patients with mild to moderate bleeding disorders

D Mehic, D Kraemmer, A Tolios, J Bücheler… - Journal of Thrombosis …, 2024 - Elsevier
Background In patients with mild-to-moderate bleeding disorders (MBD), von Willebrand
disease (VWD) is diagnosed at von Willebrand factor (VWF) levels≤ 50 IU/dL. Although …

Standardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH

RI Baker, P Choi, N Curry, J Gebhart, K Gomez… - Journal of thrombosis …, 2024 - Elsevier
In many patients referred with significant bleeding phenotype, laboratory testing fails to
define any hemostatic abnormalities. Clinical practice with respect to diagnosis and …

How to investigate mild to moderate bleeding disorders and bleeding disorder of unknown cause

A Casini, J Gebhart - International Journal of Laboratory …, 2024 - Wiley Online Library
A bleeding tendency is one of the most common complaints observed by hematologists. It is
challenging to differentiate a clinically insignificant bleeding from a bleeding phenotype that …

The ISTH‐BAT score and outcomes after endometrial ablation in women with heavy menstrual bleeding

HP Eising, MC Punt, T Schermer, JC Leemans… - …, 2023 - Wiley Online Library
Abstract Background The International Society on Thrombosis and Haemostasis bleeding
assessment tool (ISTH‐BAT), is used during the diagnostic workup of bleeding disorders …

EXAMINING VARIABILITY IN THE DIAGNOSIS AND MANAGEMENT OF PEOPLE WITH BLEEDING DISORDERS OF UNKNOWN CAUSE: COMMUNICATION FROM …

C Kelly, W Thomas, RI Baker, JS O'Donnell… - Journal of Thrombosis …, 2024 - Elsevier
Background Bleeding disorder of unknown cause (BDUC) is characterised by a bleeding
phenotype in the setting of normal haemostatic testing. No standardised diagnostic criteria …

Novel therapeutics and emerging technology in haemostasis and thrombosis: highlights from the British society for haemostasis and thrombosis annual meeting

CS Whyte, GB Morrow, JS Gauer… - Frontiers in …, 2023 - frontiersin.org
The 2023 annual meeting of the British Society for Haemostasis and Thrombosis (BSHT)
was held in Birmingham, United Kingdom. The theme of this year's meeting was novel …

Factor activity levels and bleeding scores in pediatric hemophilia carriers enrolled in the ATHNdataset

J Puetz, B Hu - Pediatric Blood & Cancer, 2023 - Wiley Online Library
Background Multiple studies have now shown that a significant proportion of hemophilia
carriers meet the criteria for having hemophilia and/or report abnormal bleeding. However …

Limited value of testing for factor XIII and α2‐antiplasmin deficiency in patients with a bleeding disorder of unknown cause

S Ariëns, A Huisman, ICLK Hovinga, RT Urbanus… - …, 2024 - Wiley Online Library
Introduction In patients with an increased bleeding tendency, extensive diagnostic blood
testing is often performed. When results of tier 1 assays of primary haemostasis are normal …

Bleeding disorder of unknown cause & unclassified bleeding disorders at US hemophilia treatment centers

C Berkowitz, K Kirkland, A Ma, NS Key - Research and Practice in …, 2024 - rpthjournal.org
Bleeding disorder of unknown cause (BDUC) is a diagnostic category encompassing
patients with an abnormal bleeding tendency yet normal hemostatic evaluation. Patients …