The hair-cell mechanotransduction channel remains unidentified. We tested whether four
transient receptor channel (TRP) family members, TRPV5, TRPV6, TRPM6, and TRPM7 …

As the start of this booklet, we begin this chapter by providing a definition on “what is
mechanosensory transduction” at the cell biological level and listing the fundamental …

In Chap. 1, we provided a general introduction for mechanotransduction. We feel that before
going to the biological details (molecule, structures, etc.), it may help to provide the readers …

Several transient receptor potential (TRP) channels have been implicated in Drosophila
hearing, including the TRPN channel NOMPC, the TRPVs Nan and Iav, and the TRPA …

Prestin (SLC26A5; Pres) nimmt eine Schlüsselstellung für die Funktion des
SäugetierInnenohres ein. Es ist das Motorprotein der ÄHZ (Zheng et al. 2000), welches in …

Inner-ear mechanotransduction relies on tip links, fine protein filaments made of cadherin-23
and protocadherin-15 that convey tension to mechanosensitive channels at the tips of hair …

The gating-spring model of a hair bundle derives from the nonlinear bundle-force vs.
displacement relationship when the bundle is stimulated from the resting state by a …

難聴はヒト集団において最も一般的な感覚器疾患であり, コミュニケーション障害などのクオリティ・
オブ・ライフに多大な影響を与える. 難聴の原因は遺伝的要因および環境要因を含むが …