Nanotechnology for boosting cancer immunotherapy and remodeling tumor microenvironment: the horizons in cancer treatment

S Gao, X Yang, J Xu, N Qiu, G Zhai - ACS nano, 2021 - ACS Publications
Immunotherapy that harnesses the human immune system to fight cancer has received
widespread attention and become a mainstream strategy for cancer treatment. Cancer …

Myeloid-derived suppressor cells as a therapeutic target for cancer

AMK Law, F Valdes-Mora, D Gallego-Ortega - Cells, 2020 - mdpi.com
The emergence of immunotherapy has been an astounding breakthrough in cancer
treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have …

[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy

Q Xiao, X Li, Y Li, Z Wu, C Xu, Z Chen, W He - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …

Paget's “seed and soil” theory of cancer metastasis: an idea whose time has come

M Akhtar, A Haider, S Rashid… - Advances in anatomic …, 2019 - journals.lww.com
The concept that the pattern of metastatic spread of cancer is not random and that cancer
cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven …

The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities

U Mehraj, RA Ganai, MA Macha, A Hamid, MA Zargar… - Cellular Oncology, 2021 - Springer
Background Breast cancer (BC), the second most common cause of cancer-related deaths,
remains a significant threat to the health and wellness of women worldwide. The tumor …

Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy

A Rani, J Stebbing, G Giamas, J Murphy - Frontiers in endocrinology, 2019 - frontiersin.org
The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

[HTML][HTML] Breast cancer genomics and immuno-oncological markers to guide immune therapies

D Hammerl, M Smid, AM Timmermans, S Sleijfer… - Seminars in cancer …, 2018 - Elsevier
There is an increasing awareness of the importance of tumor–immune cell interactions to the
evolution and therapy responses of breast cancer (BC). Not surprisingly, numerous studies …

[HTML][HTML] CircRNAs in tumor immunity and immunotherapy: Perspectives from innate and adaptive immunity

LL Yu, Q Xiao, B Yu, QL Lv, ZQ Liu, JY Yin - Cancer Letters, 2023 - Elsevier
Tumor immunotherapy is a new therapeutic approach that has been evolving in the last
decade and has dramatically changed the treatment options for cancer. Circular RNAs …

Immunotherapy in breast cancer: when, how, and what challenges?

B Henriques, F Mendes, D Martins - Biomedicines, 2021 - mdpi.com
Breast Cancer (BC) is the second most frequent cause of cancer death among women
worldwide and, although there have been significant advances in BC therapies, a significant …

Remodeled tumor immune microenvironment (TIME) parade via natural killer cells reprogramming in breast cancer

MM Elanany, DM Mostafa, NM Hamdy - Life Sciences, 2023 - Elsevier
Breast cancer (BC) is the main cause of cancer-related mortality among women globally.
Despite substantial advances in the identification and management of primary tumors …