Abstract The NF-κB/REL family of transcription factors pivotally control the inflammatory and
immune responses, as well as other genetic programmes that are central to cell growth and …

Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …

Prolonged exposure to microbial products such as lipopolysaccharide can induce a form of
innate immune memory that blunts subsequent responses to unrelated pathogens, known …

The inflammatory response is a highly regulated physiological process that is critically
important for homeostasis. A precise physiological control of inflammation allows a timely …

Inflammation is an essential response provided by the immune systems that ensures the
survival during infection and tissue injury. Inflammatory responses are essential for the …

Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that
governs the types of reactive oxygen species egressing from the organelle to affect cellular …

Homodimers of the NF-ΚB p50 subunit are transcriptionally repressive in cells, whereas they
can promote transcription in vitro, suggesting that their endogenous effects are mediated by …

Stimulus-induced nuclear factor-κB (NF-κB) activity, the central mediator of inflammatory
responses and immune function, comprises a family of dimeric transcription factors that …

Background Exposure of macrophages to bacterial products such as lipopolysaccharide
(LPS) results in activation of the NF-κB transcription factor, which orchestrates a gene …

The NF-κB family of transcription factors plays a central role in the inducible expression of
inflammatory genes during the immune response, and the proper regulation of these genes …