Neuroprotective effects of the second generation antipsychotics

AT Chen, HA Nasrallah - Schizophrenia research, 2019 - Elsevier
Background In contrast to over 30 studies reporting neurotoxicity associated with the first-
generation antipsychotics (FGAs), several published studies have reported multiple …

The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia

L Enriquez-Barreto, M Morales - Molecular and cellular therapies, 2016 - Springer
This review is focused in PI3K's involvement in two widespread mental disorders: Autism
and Schizophrenia. A large body of evidence points to synaptic dysfunction as a cause of …

Head-to-head comparison of 1-year aripiprazole long-acting injectable (LAI) versus paliperidone LAI in comorbid psychosis and substance use disorder: impact on …

I Cuomo, GD Kotzalidis, S de Persis… - Neuropsychiatric …, 2018 - Taylor & Francis
Background To overcome nonadherence in patients with psychosis switch to long-acting
injectable (LAI) antipsychotic formulations is adopted. Most oral versus LAI comparisons …

The protective effects of Mogroside V and its metabolite 11-oxo-mogrol of intestinal microbiota against MK801-induced neuronal damages

P Ju, W Ding, J Chen, Y Cheng, B Yang, L Huang… - …, 2020 - Springer
Rationale Animal models, notably with non-competitive NMDA receptor antagonist MK801,
are commonly used to investigate the mechanisms of schizophrenia and to pursue its …

Neurodevelopment in schizophrenia: the role of the wnt pathways

I Panaccione, F Napoletano… - Current …, 2013 - ingentaconnect.com
Objectives. To review the role of Wnt pathways in the neurodevelopment of schizophrenia.
Methods: Systematic PubMed search, using as keywords all the terms related to the Wnt …

Maslinic acid ameliorates NMDA receptor blockade-induced schizophrenia-like behaviors in mice

SJ Jeon, E Kim, JS Lee, HK Oh, J Zhang, Y Kwon… - …, 2017 - Elsevier
Schizophrenia is a chronic psychotic disorder characterized by positive, negative, and
cognitive symptoms. Primary treatments for schizophrenia relieve the positive symptoms but …

Paliperidone alleviates MK-801-induced damage to prefrontal cortical neurons via the PP2A/PTEN pathway

J Wang, M Li, J Zhang, Q Gao, Z Ding, J Sun - Journal of Affective Disorders, 2022 - Elsevier
Background The putative mechanisms underlying the efficacy of the US Food and Drug
Administration-approved antipsychotic drug paliperidone for the treatment of schizophrenia …

Temporal effects on death by suicide: empirical evidence and possible molecular correlates

R Bhagar, H Le-Niculescu, K Roseberry, K Kosary… - Discover mental …, 2023 - Springer
Popular culture and medical lore have long postulated a connection between full moon and
exacerbations of psychiatric disorders. We wanted to empirically analyze the hypothesis that …

Chronic haloperidol administration downregulates select BDNF transcript and protein levels in the dorsolateral prefrontal cortex of rhesus monkeys

SE Hemby, S McIntosh - Frontiers in Psychiatry, 2023 - frontiersin.org
Post-mortem studies in the prefrontal cortex and hippocampal formation from schizophrenia
patients have revealed significant disruptions in the expression molecules associated with …

Methanol extract of Ficus platyphylla ameliorates seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice

BA Chindo, H Schröder, A Becker - Phytomedicine, 2015 - Elsevier
Decoctions of Ficus plathyphylla are used in Nigeria's folk medicine to manage epilepsy for
many years and their efficacies are widely acclaimed among the rural communities of …