Alzheimer's disease (AD) is a major form of dementia. Abnormal amyloidogenic event-
mediated degeneration of cholinergic neurons in the cognitive centers of the brain has been …

In multicellular organisms, cellular behaviour is tightly regulated to allow proper embryonic
development and maintenance of adult tissue. A critical component in this control is the …

Technological advances have driven many recent advances in developmental biology. Light
sheet imaging can reveal single-cell dynamics in living three-dimensional tissues, whereas …

Optogenetic tools respond to light through one of a small number of behaviors including
allosteric changes, dimerization, clustering, or membrane translocation. Here, we describe a …

The subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) is a neurogenic niche
of the adult brain that contains neural stem cells (NSCs) able to generate excitatory …

Abstract β-Catenin is a well-established driver of many cancers; however, there are
challenges in developing agents targeting β-catenin for clinical use. Recent progress has …

Diseased or injured nervous systems lead to lifelong disability and even death due to their
limited self-repair and regenerative capability. For successful neuronal regeneration and …

The role of WNT/β‐catenin signalling in mouse neocortex development remains ambiguous.
Most studies demonstrate that WNT/β‐catenin regulates progenitor self‐renewal but others …

Wnt signal transduction is controlled by the destruction complex (DC), a condensate
comprising scaffold proteins and kinases that regulate β-catenin stability. Overexpressed DC …

Protein clustering is a powerful form of optogenetic control, yet remarkably few proteins are
known to oligomerize with light. Recently, the photoreceptor BcLOV4 was found to form …