Toripalimab: the first domestic anti-tumor PD-1 antibody in China

L Zhang, B Hao, Z Geng, Q Geng - Frontiers in immunology, 2022 - frontiersin.org
Toripalimab (Tuoyi™) is a selective, recombinant, humanized monoclonal antibody against
programmed death protein 1 (PD-1) developed by Shanghai Junshi Bioscience Co., Ltd …

Hepatocellular carcinoma downstaging for liver transplantation in the era of systemic combined therapy with anti‐VEGF/TKI and immunotherapy

NH Tran, S Muñoz, S Thompson, CL Hallemeier… - Hepatology, 2022 - journals.lww.com
Hepatocellular carcinoma remains a global health challenge affecting close to 1 million
cases yearly. Liver transplantation provides the best long‐term outcomes for those meeting …

[HTML][HTML] Lenvatinib plus anti-PD-1 antibodies as conversion therapy for patients with unresectable intermediate-advanced hepatocellular carcinoma: a single-arm …

W Zhang, S Tong, B Hu, T Wan, H Tang… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Over 70% of the patients with hepatocellular carcinoma (HCC) are diagnosed
at an advanced stage and lose the opportunity for radical surgery. Combination therapy of …

Changes in therapeutic options for hepatocellular carcinoma in Asia

S Ogasawara, K Koroki, H Kanzaki… - Liver …, 2022 - Wiley Online Library
The incidence rate of hepatocellular carcinoma (HCC) is expected to increase, with most
cases occurring in Asia. In some parts of Asia, the occurrence of HCC developing from …

Immune checkpoint inhibitors in the treatment of hepatocellular carcinoma

Z Akbulut, B Aru, F Aydın… - Frontiers in …, 2024 - frontiersin.org
Despite advances in cancer treatment, hepatocellular carcinoma (HCC), the most common
form of liver cancer, remains a major public health problem worldwide. The immune …

Emerging insights on immunotherapy in liver cancer

Y Zhang, X Zhang, M Kuang, J Yu - Antioxidants & Redox Signaling, 2022 - liebertpub.com
Significance: Hepatocellular carcinoma (HCC) is a liver malignancy with high mortality rate,
limited treatment options, and poor prognosis. Sorafenib has been the only systemic …

Anti-PD-1/PD-L1 immunotherapy in conversion treatment of locally advanced hepatocellular carcinoma

J Chen, D Zhang, Y Yuan - Clinical and Experimental Medicine, 2023 - Springer
Curative surgery and locoregional therapy are radical therapies for patients with HCC. But
more than 80% of HCC patients cannot be fitful for radical therapies because of local …

Efficacy and safety of monotherapy and combination therapy of immune checkpoint inhibitors as first-line treatment for unresectable hepatocellular carcinoma: a …

Q Lei, X Yan, H Zou, Y Jiang, Y Lai, COL Ung, H Hu - Discover Oncology, 2022 - Springer
Background Hepatocellular carcinoma (HCC) is one of the cancers with the highest
morbidity and mortality. Sorafenib used to be the main treatment for unresectable HCC …

[HTML][HTML] Efficacy and safety of toripalimab with fruquintinib in the third-line treatment of refractory advanced metastatic colorectal cancer: results of a single-arm, single …

S Ma, R Chen, L Duan, C Li, T Yang… - Journal of …, 2023 - ncbi.nlm.nih.gov
Background The most effective treatment with immune checkpoint inhibitors (ICIs) is limited
to the microsatellite instability high (MSI-H) subgroup of advanced colorectal cancer. ICIs are …

Neoadjuvant systemic therapy for hepatocellular carcinoma

RC Chick, SM Ruff, TM Pawlik - Frontiers in immunology, 2024 - frontiersin.org
Surgical resection and liver transplant remain the only curative therapies for most patients
with hepatocellular carcinoma (HCC). Systemic therapy options have typically been …