[HTML][HTML] Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients

DV Ablashi, HB Eastman, CB Owen, MM Roman… - Journal of Clinical …, 2000 - Elsevier
Background: HHV-6 is a ubiquitous virus and its infection usually occurs in childhood and
then becomes a latent infection. HHV-6 reactivation has been shown to play a role in the …

Real-time quantitative PCR for human herpesvirus 6 DNA

G Locatelli, F Santoro, F Veglia, A Gobbi… - Journal of clinical …, 2000 - Am Soc Microbiol
The diagnosis of human herpesvirus 6 (HHV-6) infection represents a complex issue
because the most widely used diagnostic tools, such as immunoglobulin G antibody titer …

The spectrum of human herpesvirus 6 infection: from roseola infantum to adult disease

MY Stoeckle - Annual review of medicine, 2000 - annualreviews.org
▪ Abstract Human herpesvirus 6 is the causative agent of roseola infantum, a generally
benign rash illness of infants. Most persons acquire HHV-6 infection by age 2 years, and …

Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo

C Manichanh, C Olivier-Aubron… - Journal of General …, 2001 - microbiologyresearch.org
After serial passage in the presence of increasing concentrations of ganciclovir (GCV) in
vitro, a human herpesvirus-6 (HHV-6) mutant exhibiting a decreased sensitivity to the drug …

Close encounters of the first kind: innate sensors and multiple sclerosis

L Fernández-Paredes, RP de Diego, C de Andrés… - Molecular …, 2017 - Springer
Although autoimmune diseases by definition imply adaptive immune system pathologies,
growing evidence points to the relevance of innate receptors in modulating the initiation and …

[HTML][HTML] The HHV6 paradox: ubiquitous commensal or insidious pathogen? A two-step in situ PCR approach

BM Blumberg, DJ Mock, JM Powers, M Ito… - Journal of clinical …, 2000 - Elsevier
Background: Progressive multifocal leukoencephalopathy (PML) and multiple sclerosis (MS)
are demyelinative diseases of the central nervous system (CNS). PML occurs mostly in …

Naturally processed HLA‐DR3‐restricted HHV‐6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T‐cell responses

A Becerra‐Artiles, J Cruz, JD Leszyk… - European Journal of …, 2019 - Wiley Online Library
Human herpes virus 6B (HHV‐6B) is a widespread virus that infects most people early in
infancy and establishes a chronic life‐long infection with periodic reactivation. CD4 T cells …

Langerhans cell histiocytosis: A primary viral infection of bone?: Human herpes virus 6 latent protein detected in lymphocytes from tissue of children

MP Glotzbecker, DF Carpentieri… - Journal of Pediatric …, 2004 - journals.lww.com
To better understand the etiology of Langerhans cell histiocytosis (LCH), the authors
analyzed tissue from 35 children diagnosed with LCH for the presence of viral proteins and …

Human herpesvirus 6 infects dendritic cells and suppresses human immunodeficiency virus type 1 replication in coinfected cultures

H Asada, V Klaus-Kovtun, H Golding, SI Katz… - Journal of …, 1999 - Am Soc Microbiol
ABSTRACT Human herpesvirus 6 (HHV-6) has been implicated as a cofactor in the
progressive loss of CD4+ T cells observed in AIDS patients. Because dendritic cells (DC) …

Genome-wide approach to the CD4 T-cell response to human herpesvirus 6B

DJ Hanson, O Tsvetkova, GF Rerolle… - Journal of …, 2019 - Am Soc Microbiol
ABSTRACT Human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) are population-
prevalent betaherpesviruses with intermittent lytic replication that can be pathogenic in …