Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …

Neuropathological and in vivo studies have revealed a tight relationship between tau
pathology and cognitive impairment across the Alzheimer's disease spectrum. However, tau …

Defective autophagy contributes to Alzheimer disease (AD) pathogenesis although
evidence is conflicting on whether multiple stages are impaired. Here, for the first time, we …

Autophagy, the major degradative pathway for organelles and long-lived proteins, is
essential for the survival of neurons. Mounting evidence has implicated defective autophagy …

The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis
because of the complexity of AD and the overlap of its early-stage markers with normal …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for
degrading normal and aggregated proteins, particularly under stress or injury conditions …

Glutaredoxins utilize the reducing power of glutathione to maintain and regulate the cellular
redox state and redox-dependent signaling pathways, for instance, by catalyzing reversible …