The neuroscience of drug reward and addiction
ND Volkow, M Michaelides, R Baler - Physiological reviews, 2019 - journals.physiology.org
Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …
The molecular basis of drug addiction: linking epigenetic to synaptic and circuit mechanisms
EJ Nestler, C Lüscher - Neuron, 2019 - cell.com
Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …
develops compulsive use that does not stop even in light of major negative consequences …
[HTML][HTML] How machine learning is used to study addiction in digital healthcare: A systematic review
Long-term use of drugs can sometimes result in brain damage that greatly affects a person's
psychology and sometimes become indecent. This paper examines psychological disorders …
psychology and sometimes become indecent. This paper examines psychological disorders …
How the epigenome integrates information and reshapes the synapse
RR Campbell, MA Wood - Nature Reviews Neuroscience, 2019 - nature.com
In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …
encodes information to form long-lasting memories that lead to stable changes in behaviour …
Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens
CD Teague, EJ Nestler - Molecular psychiatry, 2022 - nature.com
Repeated cocaine use induces coordinated changes in gene expression that drive plasticity
in the nucleus accumbens (NAc), an important component of the brain's reward circuitry, and …
in the nucleus accumbens (NAc), an important component of the brain's reward circuitry, and …
A trauma model of substance use: Elaboration and preliminary validation
A Schimmenti, J Billieux, G Santoro, S Casale… - Addictive …, 2022 - Elsevier
The current study expands on and integrates previous theoretical models concerning the
pathways that link child maltreatment to substance use disorder. The proposed model …
pathways that link child maltreatment to substance use disorder. The proposed model …
NIDA's medication development priorities in response to the Opioid Crisis: ten most wanted
K Rasmussen, DA White, JB Acri - Neuropsychopharmacology, 2019 - nature.com
The United States is in the midst of a horrific problem. The rampant misuse of opioid drugs
(both prescribed and illegal), now known as the Opioid Crisis, has had grave effects on both …
(both prescribed and illegal), now known as the Opioid Crisis, has had grave effects on both …
Drug addiction: a curable mental disorder?
Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …
The opioid crisis and the future of addiction and pain therapeutics
NP Coussens, GS Sittampalam, SG Jonson… - Journal of pharmacology …, 2019 - ASPET
Opioid misuse and addiction are a public health crisis resulting in debilitation, deaths, and
significant social and economic impact. Curbing this crisis requires collaboration among …
significant social and economic impact. Curbing this crisis requires collaboration among …
Food addiction and psychosocial adversity: biological embedding, contextual factors, and public health implications
The role of stress, trauma, and adversity particularly early in life has been identified as a
contributing factor in both drug and food addictions. While links between traumatic stress …
contributing factor in both drug and food addictions. While links between traumatic stress …