▪ Abstract Most chloroplast proteins are nuclear encoded, synthesized as larger precursor
proteins in the cytosol, posttranslationally imported into the organelle, and routed to one of …

Nucleocytoplasmic transport is a complex process that consists of the movement of
numerous macromolecules back and forth across the nuclear envelope. All macromolecules …

We have found that the mammalian Ran GTPase–activating protein RanGAP1 is highly
concentrated at the cytoplasmic periphery of the nuclear pore complex (NPC), where it …

The importin-α/β complex and the GTPase Ran mediate nuclear import of proteins with a
classical nuclear localization signal. Although Ran has been implicated also in a variety of …

Using a monoclonal antibody, mAb 203-37, we have identified a polypeptide of M r∼ 270
kD (p270) as a general constituent of the intranuclear filaments attached to the …

Nascent pre-mRNAs associate with the abundant heterogeneous nuclear RNP (hnRNP)
proteins and remain associated with them throughout the time they are in the nucleus. The …

Nup153 is a large (153 kD) O-linked glyco-protein which is a component of the basket
structure located on the nucleoplasmic face of nuclear pore complexes. This protein exhibits …

We identified a Saccharomyces cerevisiae peroxisomal membrane protein, Pex13p, that is
essential for protein import. A point mutation in the COOH-terminal Src homology 3 (SH3) …

Macromolecular trafficking across the nuclear envelope involves interactions between
cytosolic transport factors and nuclear pore complex proteins. The p62 complex, an …

Heterogeneous nuclear ribonucleoprotein A1 contains a sequence, termed M9, that
functions as a potent nuclear localization signal (NLS) yet bears no similarity to the …