Despite 80 years of progress in modern small molecule drug discovery, medicinal chemists
still struggle to minimize the number and duration of design cycles required to optimize hit …

Triazole demonstrates distinctive physicochemical properties, characterized by weak
basicity, various dipole moments, and significant dual hydrogen bond acceptor and donor …

Chiral amine synthesis remains a significant challenge in accelerating the design cycle of
drug discovery programs. A zirconium hydride, due to its high oxophilicity and lower …

In this study, we successfully developed two novel vinylene‐linked covalent organic
frameworks (COFs) using 2‐connected 3, 6‐dimethylpyridazine through Knoevenagel …

Hansen solubility parameters (HSPs) have three components, δd, δp and δh, accounting for
dispersion forces, polar forces, and hydrogen bonding of a molecule, which were designed …

Pyridazine, as a privileged scaffold, has been extensively utilized in drug development due
to its multiple biological activities. Especially around its distinctive anticancer property, a …

Visualizing the distribution of small-molecule drugs in living cells is an important strategy for
developing specific, effective, and minimally toxic drugs. As an alternative to fluorescence …

Sulfonamides have gained prominence as versatile agents in cancer therapy, effectively
targeting a spectrum of cancer-associated enzymes. This review provides an extensive …

The methoxy substituent is prevalent in natural products and, consequently, is present in
many natural product-derived drugs. It has also been installed in modern drug molecules …

Background The efficacy of current drugs against hookworms at a single dose is highly
variable across regions, age groups and infection intensity. Extensive and repeated use of …