Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …

Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …

Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are
repaired by the ESCRT machinery. Here, we describe an additional mechanism for …

The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Mitochondria are highly dynamic organelles whose fragmentation by fission is critical to their
functional integrity and cellular homeostasis. Here, we develop a method via optogenetic …

Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling
and the catabolic turnover of macromolecules. How these janus-faced activities are …

Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

Mitochondrial and lysosomal functions are intimately linked and are critical for cellular
homeostasis, as evidenced by the fact that cellular senescence, aging, and multiple …