This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Vitamin D is known to elicit a vasoprotective effect, while vitamin D deficiency is a risk factor
for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent …

Blood–brain barrier (BBB) breakdown after ischemic stroke exacerbates brain injury and
BBB senescence can cause severe neurological deficits in aged ischemic stroke population …

The endothelium forms an important part of the vasculature and is involved in promoting an
atheroprotective environment via the complementary actions of endothelial cell-derived …

The aging of the central nervous system and the development of incapacitating neurological
diseases like Alzheimer's disease (AD) are generally associated with a wide range of …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

The activity of the endothelial nitric oxide synthase (eNOS) can be regulated independently
of an increase in Ca2+ by the phosphorylation of Ser1177 but results only in a low nitric …

Recent epidemiologic studies have shown that aerobic exercise, one of lifestyle
modifications, reduces cardiovascular morbidity and mortality in the general population …