Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Background Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric
symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP) …

The locus coeruleus is the initial site of Alzheimer's disease neuropathology, with
hyperphosphorylated Tau appearing in early adulthood followed by neurodegeneration in …

Neurodegenerative diseases of the brain pose a major and increasing global health
challenge, with only limited progress made in developing effective therapies over the last …

Neural dynamics are shaped and constrained by the projections of a small nucleus in the
pons: the noradrenergic locus coeruleus (LC). Much like a bow to the brain's violin, activity in …

Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in
Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some …

Background Parkinson's disease (PD) causes a loss of neuromelanin‐positive,
noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …