Over the past 15 years the privileged structure concept has emerged as a fruitful approach to
the discovery of novel biologically active molecules. Privileged structures are molecular …

Fluorine-containing nucleoside analogs (NAs) represent a significant class of the US FDA-
approved chemotherapeutics widely used in the clinic. The incorporation of fluorine into …

The discovery in 1959 of stable nitroxide‐based free radicals such as the prototypical 2, 2, 6,
6‐tetramethylpiperidine‐1‐oxyl (TEMPO) led to their use as electron spin resonance (ESR) …

Click reaction approach toward the synthesis of two sets of novel 1, 2, 3-triazolyl linked
uridine derivatives 19a–19g and 21a–21g was achieved by Cu (I)-catalyzed 1, 3-dipolar …

“Click chemistry” was explored to synthesize two series of 2-(1, 2, 3-triazolyl) adenosine
derivatives (1− 14). Binding affinity at the human A1, A2A, and A3ARs (adenosine receptors) …

Nucleoside derivatives, in particular those featuring uridine, are familiar components of the
nucleoside family of bioactive natural products. The structural complexity and biological …

The Vorbrüggen glycosylation reaction was adapted into a one-step 5 min/130° C
microwave assisted reaction. Triethanolamine in acetontrile containing 2% water was …

Pyrimidine and purine nucleosides have a remarkable and comprehensive impact on
medicinal chemistry and pharmaceutical industries. They become key parts of the growing …

Succinyl‐cycloSal‐phosphate triesters of ribo‐and 2′‐deoxyribonucleosides were attached
to aminomethyl polystyrene as an insoluble solid support and reacted with phosphate …

Herein, we report the synthesis and the use of new N-1-dinitrophenyl-inosine based solid
supports, in which the C-2 of the purine base is strongly activated toward the attack of N …