Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

A growing body of evidence demonstrates the important role of the noradrenergic system in
the pathogenesis of many neurodegenerative processes, especially Alzheimer's disease …

The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein
pathology in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The …

Hyperphosphorylated tau in the locus coeruleus (LC) is ubiquitous in prodromal Alzheimer's
disease (AD), and LC neurons degenerate as AD progresses. Hyperphosphorylated tau …

BACKGROUND The locus coeruleus (LC) is the primary source of norepinephrine in the
brain and regulates arousal and sleep. Animal research shows that it plays important roles …

The locus coeruleus (LC) is the site where tau accumulation is preferentially observed
pathologically in Alzheimer's disease (AD) patients, but the changes in gray matter co …

Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a
lot of attention because of its emerging role in cognitive and psychiatric disorders. Although …

Catecholaminergic transmission plays an essential role in both physiological and
pathological cognitive functions. Plastic changes subserving learning and memory …