The JAK-STAT signaling pathway plays a central role in signal transduction in hematopoietic
cells, as well as in cells of the immune system. The occurrence in most patients affected by …

Clonal alterations in hematopoietic cells occur during aging and are often associated with
the establishment of a subclinical inflammatory environment. Several age-related conditions …

Immunosuppressive drugs used in the transplantation period are generally defined as
induction and maintenance therapy. The use of immunosuppressants, which are particularly …

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven
by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying …

Prior studies have reported high response rates with recombinant interferon-α (rIFN-α)
therapy in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To …

Background In the pivotal RESPONSE study, ruxolitinib, a Janus kinase (JAK) 1 and JAK2
inhibitor, was superior to best available therapy at controlling haematocrit and improving …

Elevated hematocrit is associated with cardiovascular risk; however, the causality and
mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk …

Abstract Disease overview Polycythemia Vera (PV) and essential thrombocythemia (ET) are
myeloproliferative neoplasms respectively characterized by erythrocytosis and …

Myeloproliferative Neoplasms | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Myeloid neoplasms, including acute myeloid leukemia (AML), myeloproliferative neoplasms
(MPNs), and myelodysplastic syndromes (MDS), feature clonal dominance and remodeling …