Osteoporosis, genetics and hormones

R Rizzoli, JP Bonjour, SL Ferrari - Journal of molecular …, 2001 - jme.bioscientifica.com
Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

Genetics of osteoporosis

JA Eisman - Endocrine reviews, 1999 - academic.oup.com
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The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal …

C Gross, TR Eccleshall, PJ Malloy… - Journal of Bone and …, 1996 - Wiley Online Library
We examined the association of bone mineral density (BMD) with a polymorphism in the
gene encoding the vitamin D receptor (VDR) that causes a change in the predicted protein …

Bone mineral density in girls with forearm fractures

A Dr. Goulding, R Cannan, SM Williams… - Journal of Bone and …, 1998 - academic.oup.com
In childhood, the most common site of fracture is the distal forearm. To determine whether
young girls with these fractures have low bone density more commonly than fracture‐free …

Familial resemblance for bone mineral mass is expressed before puberty

S Ferrari, R Rizzoli, D Slosman… - The Journal of Clinical …, 1998 - academic.oup.com
Genetic factors are known to explain a major proportion of peak bone mineral mass
variance. Whether the influence of these genetic factors is expressed before the pubertal …

Vitamin D Receptor Gene Fok1 Polymorphism Predicts Calcium Absorption and Bone Mineral Density in Children

SK Ames, KJ Ellis, SK Gunn… - Journal of Bone and …, 1999 - academic.oup.com
The vitamin D receptor (VDR) gene has been implicated as one of the major genetic
components of osteoporosis. We evaluated the relationship between markers of mineral …

Determinants of peak bone mass and mechanisms of bone loss

R Rizzoli, JP Bonjour - Osteoporosis international, 1999 - search.proquest.com
Peak bone mass (PBM) is defined as the amount of bony tissue present at the end of
skeletal maturation [1]. Bone strength is mainly determined by volumetric density, ie, the …

Smoking is associated with lower bone mineral density and reduced cortical thickness in young men

M Lorentzon, D Mellström, E Haug… - The Journal of Clinical …, 2007 - academic.oup.com
Context: Smoking has previously been associated with reduced areal bone mineral density
(aBMD) in elderly subjects, but the association remains controversial in adolescents …

Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD study

M Lorentzon, C Swanson, N Andersson… - Journal of Bone and …, 2005 - academic.oup.com
In this study, we evaluated the predictive roles of sex steroids for skeletal parameters in
young men (n= 1068) at the age of peak bone mass. Serum free estradiol was a negative …

Vitamin D Receptor Gene Start Codon Polymorphisms (FokI) and Bone Mineral Density: Interaction with Age, Dietary Calcium, and 3′‐End Region Polymorphisms

S Ferrari, R Rizzoli, D Manen… - Journal of Bone and …, 1998 - academic.oup.com
Osteoporosis is a polygenic disease, whose determining loci have not yet been identified.
Vitamin D receptor (VDR) gene polymorphisms in the 3′‐end region (as determined by the …