Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

As the field of translational 'omics has progressed, refined classifiers at both genomic and
proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically …

Overcoming anticancer drug resistance is a major challenge in cancer therapy, requiring
innovative strategies that consider the extensive tumor heterogeneity and adaptability. We …

Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in
the research of tumor progression. Treg cells have the function of inhibiting the immune …

Immune checkpoint blockade therapy (ICBT) targeting checkpoints, such as, cytotoxic T‐
lymphocyte associated protein‐4 (CTLA‐4), programmed death‐1 (PD‐1), or programmed …

Oral squamous cell carcinoma (SCC) is a prevalent malignant disease worldwide,
especially so in Taiwan. Early-or even preclinical-stage detection is critical for reducing …

Abstract The enzyme glutaminase-1 (GLS-1) has shown a clear and coherent implication in
the progression and exacerbation of different aggressive tumors such as glioblastoma …

Cancer cells undergo metabolic adaptations to sustain their growth and proliferation under
several stress conditions thereby displaying metabolic plasticity. Epigenetic modification is …

Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate
(ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the …

Through genetic and epigenetic alterations, cancer cells present the immune system with a
diversity of antigens or neoantigens, which the organism must distinguish from self. The …