Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Heart disease is the leading cause of death worldwide. Cardiomyopathy is a disease
characterized by the heart muscle damage, resulting heart in a structurally and functionally …

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C,
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …

Cardiovascular disease (CVD) remains the leading cause of mortality globally, so further
investigation is required to identify its underlying mechanisms and potential targets for its …

Rationale: LMNA (Lamin A/C), a nuclear membrane protein, interacts with genome through
lamin-associated domains (LADs) and regulates gene expression. Mutations in the LMNA …

Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic,
and metabolomic abnormalities. Emerging evidence has recently consolidated the presence …

Heart disease is a worldwide health menace. Both intractable primary and secondary
cardiomyopathies contribute to malignant cardiac dysfunction and mortality. One of the key …

With the development and advancement of next-generation sequencing (NGS), genetic
analysis is becoming more accessible. High-throughput genetic studies using NGS have …

Precision medicine promises to dramatically improve patient outcomes and reduce health
care costs through a shift in focus from disease treatment to prevention and individualized …

Mutations in nuclear envelope proteins (NEPs) cause devastating genetic diseases, known
as envelopathies, that primarily affect the heart and skeletal muscle. A mutation in the NEP …