Towards in vitro models for reducing or replacing the use of animals in drug testing | Nature
Biomedical Engineering Skip to main content Thank you for visiting nature.com. You are using …

Microphysiological systems (MPSs), also known as organ-on-chip or disease-on-chip, have
recently emerged to reconstitute the in vivo cellular microenvironment of various organs and …

In the attempt to overcome the increasingly recognized shortcomings of existing in vitro and
in vivo models, researchers have started to implement alternative models, including …

Abstract The National Center for Advancing Translational Sciences (NCATS) Assay
Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development …

Over the last decade, bioengineering has seen a sustained growth in scientific publications,
patents, and clinical trials. As the field attempts to bridge the gap between discovery and …

Biotherapeutics hold great promise for the treatment of severe diseases and offer innovative
possibilities for new treatments that target previously unaddressed medical needs. Despite …

Microphysiological systems (MPS) are designed to recapitulate aspects of tissue/organ
physiology in vivo, thereby providing potential value in safety and efficacy assessments of …

Diabetes has become an increasingly prominent global issue afflicting 10% of world's
population where type 2 diabetes (T2D) comprises the majority of those diagnosed. T2D …

Personalized medicine targets a patient's unique characteristics to provide more accurate
diagnoses and effective treatment. Prevention, diagnosis, and progression for a single …