Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation

SM Hoy, GM Keating - Drugs, 2011 - Springer
Dexmedetomidine (Precedex®), a pharmacologically active dextroisomer of medetomidine,
is a selective α 2-adrenergic receptor agonist. It is indicated in the US for the sedation of …

[PDF][PDF] Intravenous infusions in chronic pain management

B Kosharskyy, W Almonte, N Shaparin… - Pain physician, 2013 - ivketamine.com
In the United States, millions of Americans are affected by chronic pain, which adds heavily
to national rates of morbidity, mortality, and disability, with an ever-increasing prevalence …

A comparison of intrathecal dexmedetomidine, clonidine, and fentanyl as adjuvants to hyperbaric bupivacaine for lower limb surgery: A double blind controlled study

V Mahendru, A Tewari, S Katyal, A Grewal… - Journal of …, 2013 - journals.lww.com
Background: Various adjuvants are being used with local anesthetics for prolongation of
intraoperative and postoperative analgesia. Dexmedetomidine, the highly selective 2 …

Comparison of opioid-based and opioid-free TIVA for laparoscopic urological procedures in obese patients

S Bhardwaj, K Garg, S Devgan - Journal of Anaesthesiology …, 2019 - journals.lww.com
Results: There were no differences in the demographic and intraoperative hemodynamic
profile between the groups. Incidence of respiratory depression, defined as fall in saturation …

Interpatient variability in dexmedetomidine response: a survey of the literature

SF Holliday, SL Kane-Gill, PE Empey… - The Scientific World …, 2014 - Wiley Online Library
Fifty‐five thousand patients are cared for in the intensive care unit (ICU) daily with sedation
utilized to reduce anxiety and agitation while optimizing comfort. The Society of Critical Care …

[HTML][HTML] Preanesthetic dexmedetomidine 1 µg/kg single infusion is a simple, easy, and economic adjuvant for general anesthesia

HW Shin, HN Yoo, DH Kim, H Lee… - Korean J …, 2013 - synapse.koreamed.org
Background Dexmedetomidine is an α 2-adrenoreceptor agonist with sedative, analgesic
and anxiolytic effects, and it has more selective α 2-adrenergic effect than clonidine. We …

The efficacy and safety of epidural dexmedetomidine and clonidine with bupivacaine in patients undergoing lower limb orthopedic surgeries

SI Shaikh, SB Mahesh - Journal of Anaesthesiology Clinical …, 2016 - journals.lww.com
Results: Demographic data, surgical characteristics cardio-respiratory parameters, side-
effect profile were comparable and statistically not significant in both the groups. However …

Dexmedetomidine: a review of a newer sedative in dentistry

A Devasya, M Sarpangala - Journal of Clinical Pediatric …, 2015 - meridian.allenpress.com
Dexmedetomidine is a central α-2 agonist, similar to Clonidine, but 8 times more specific for
the central α-2 receptor which causes sedation with minimal depression of respiration …

Chirality and anaesthetic drugs: A review and an update

S Mitra, P Chopra - Indian Journal of Anaesthesia, 2011 - journals.lww.com
Many molecules can exist as right-handed and left-handed forms that are non-
superimposable mirror images of each other. They are known as enantiomers or substances …

Preventive effects of dexmedetomidine on the liver in a rat model of acid‐induced acute lung injury

V Şen, A Güzel, H Selimoğlu Şen, A Ece… - BioMed Research …, 2014 - Wiley Online Library
The aim of this study was to examine whether dexmedetomidine improves acute liver injury
in a rat model. Twenty‐eight male Wistar albino rats weighing 300–350 g were allocated …