Opioids are very effective analgesics, but they are also highly addictive. Methadone is used
to treat opioid dependence (OD), acting as a selective agonist at the μ-opioid receptor …

Clinical pharmacogenomics (PGx) has the potential to make pharmacotherapy safer and
more effective by utilizing genetic patient data for drug dosing and selection. However …

Understanding and predicting inter-individual differences related to the success of drug
therapy is of tremendous importance, both during drug development and for clinical …

There is a strong and ever-growing body of evidence regarding the use of
pharmacogenomics to inform cardiovascular pharmacology. However, there is no common …

Logistics and (cost-) effectiveness of pharmacogenetic (PGx)-testing may be optimized when
delivered through a pre-emptive panel-based approach, within a clinical decision support …

Conventional medicines optimisation interventions in people with multimorbidity and
polypharmacy are complex and yet limited; a more holistic and integrated approach to …

There have recently been significant advances in the field of oral anticoagulation, but these
have also led to many controversies. Warfarin is still the commonest drug used for clotting …

Introducción y objetivos Analizar la prevalencia en España de mal control de la
anticoagulación con antagonistas de la vitamina K en pacientes con fibrilación auricular no …

In the 15 years following the release of the first complete human genome sequences, our
understanding of rare and common genetic variation as determinants of cardiovascular …

Objective Warfarin anticoagulation management requires sequential decision-making to
adjust dosages based on patients' evolving states continuously. We aimed to leverage …