Anticoagulation is the most-important intervention to prevent stroke in patients with atrial
fibrillation (AF). Despite a lower point prevalence of AF in Asian communities and Asian …

Background Although warfarin and other vitamin K antagonists (VKAs) are the most widely
used oral anticoagulants for the prevention and treatment of thromboembolic events, a …

We aimed to assess the cost-effectiveness of pharmacogenetic-guided dosing of warfarin in
patients with atrial fibrillation (AF) in the United Kingdom and Sweden. Data from EU-PACT …

Objective To comprehensively assess the pharmacogenomic evidence of routinely used
drugs for clinical utility. Methods Between January 2, 2011, and May 31, 2013, we assessed …

Despite strong pharmacological support, association studies using genotype-predicted
phenotype as a variable have yielded conflicting or inconclusive evidence to promote …

Warfarin is an anticoagulant that acts by reducing the activity of vitamin K-dependent clotting
factors. It is used in the prevention and treatment of thrombotic disorders. The dose of …

Importance Genetic biomarkers that predict a drug's efficacy or likelihood of toxicity are
assuming increasingly important roles in the personalization of pharmacotherapy, but …

Aim: This study is aimed to find the best predictive model for warfarin stable dosage.
Materials & methods: Seven models, namely multiple linear regression (MLR), artificial …

The evolution of the modern clinical trial dates back at least to the eighteenth century [1, 2].
Lind, in his classical study on board the Salisbury, evaluated six treatments for scurvy in 12 …

Warfarin has a very narrow therapeutic window and obvious interindividual variability in its
effects, with many factors contributing to the body's response. Algorithms incorporating …