Background: The main aims of the present study were to develop a pharmacogenetic-based
warfarin dosing algorithm and to validate it in a highly admixed population. Materials & …

The field of genetics and genomics has advanced considerably with the achievement of
recent milestones encompassing the identification of many loci for cardiovascular disease …

The task of developing ESC Guidelines covers not only the integration of the most recent
research, but also the creation of educational tools and implementation programmes for the …

Aim Adverse drug events lead to increased morbidity, mortality and health care costs.
Pharmacogenetic testing that guides drug prescribing has the potential to reduced adverse …

We constructed a cost-effectiveness model to assess the clinical and economic value of a
CDS alert program that provides pharmacogenomic (PGx) testing results, compared to no …

Cubane was recently validated as a phenyl ring (bio) isostere, but highly strained caged
carbocyclic systems lack π character, which is often critical for mediating key biological …

Warfarin, acenocoumarol, phenprocoumon, and fluindione are commonly prescribed oral
anticoagulants for the prevention and treatment of thromboembolic disorders. These …

The emerging availability of genomic and electronic health data in large populations is a
powerful tool for research that has drawn interest in bringing precision medicine to diabetes …

The prescription of new oral anticoagulants is on the rise. As opposed to vitamin K
antagonists and heparins the new agents have single targets in the coagulation cascade …

In this review, we lay out 3 areas currently being evaluated for incorporation of genetic
information into clinical practice related to atherosclerosis. The first, familial …