Heavy alcohol consumption is a major cause of morbidity and mortality. Globally, alcohol per-
capita consumption rose from 5.5 litres in 2005 to 6.4 litres in 2016 and is projected to …

Liver is the largest solid organ in the body that performs over 100 functions. It removes the
toxins and waste products from the blood stream, maintains healthy blood sugar levels …

The last 10 years have revolutionized our basic understanding of nonalcoholic fatty liver
disease and consequent liver cancer. It has become clear that several innate and adaptive …

The past decade has witnessed significant advances in the systemic treatment of advanced
hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies …

Systemic therapy for advanced hepatocellular carcinoma has expanded at an
unprecedented pace over the past 5 years. After tyrosine kinase inhibitors dominated the …

Aim This study aimed to investigate the utility of C-reactive protein (CRP) and alpha-
fetoprotein (AFP) in immunotherapy (CRAFITY) score in hepatocellular carcinoma (HCC) …

Background & Aims We elucidated the clinical and immunologic implications of serum IL-6
levels in patients with unresectable hepatocellular carcinoma (HCC) treated with …

Objective We conducted the first meta-analysis to identify the predictive significance of
baseline blood biomarkers (such as neutrophil to lymphocyte ratio (NLR), early alpha …

Immune checkpoint inhibitors (ICIs) have dramatically enhanced the treatment outcomes for
diverse malignancies. Yet, only 15–60% of patients respond significantly. Therefore …

Abstract Background & Aims Immune checkpoint inhibitors (ICIs) alone or in combination
with other ICIs or vascular endothelial growth factor pathway inhibitors are therapeutic …