Male factor infertility affects 50% of infertile couples worldwide; the most severe form, non-
obstructive azoospermia (NOA), affects 10–15% of infertile males. Treatment for individuals …

Non-obstructive azoospermia (NOA) is a disease characterized by spermatogenesis failure
and comprises phenotypes such as hypospermatogenesis, mature arrest, and Sertoli cell …

Environmental toxicants, such as cadmium, found in foods, water, and consumer products
are known to induce male reproductive dysfunction. However, the underlying molecular …

Advanced reproductive technologies are utilized to identify the genetic mutations that lead to
spermatogenic impairment, and allow informed genetic counseling to patients to prevent the …

Background High-throughput single-cell RNA sequencing (scRNA-seq) is widely used in
spermatogenesis. However, it only reveals short reads in germ and somatic cells, limiting the …

BACKGROUND: Non-obstructive azoospermia (NOA) is defined by the complete absence of
spermatozoa in repeated ejaculate samples. The vast majority of cases remain unexplained …