The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
[HTML][HTML] Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Pseudomonas aeruginosa is an opportunistic pathogen affecting immunocompromised
patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) …
patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) …
The SOS system: a complex and tightly regulated response to DNA damage
KH Maslowska, K Makiela‐Dzbenska… - Environmental and …, 2019 - Wiley Online Library
Genomes of all living organisms are constantly threatened by endogenous and exogenous
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …
Recent functional insights into the role of (p) ppGpp in bacterial physiology
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
Insights into the phylogeny and coding potential of microbial dark matter
Genome sequencing enhances our understanding of the biological world by providing
blueprints for the evolutionary and functional diversity that shapes the biosphere. However …
blueprints for the evolutionary and functional diversity that shapes the biosphere. However …
[PDF][PDF] Genomic expansion of domain archaea highlights roles for organisms from new phyla in anaerobic carbon cycling
Background Archaea represent a significant fraction of Earth's biodiversity, yet they remain
much less well understood than Bacteria. Gene surveys, a few metagenomic studies, and …
much less well understood than Bacteria. Gene surveys, a few metagenomic studies, and …
Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa
In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas
aeruginosa infections has gradually decreased. This pathogen can be observed in several …
aeruginosa infections has gradually decreased. This pathogen can be observed in several …
Bacterial persister cell formation and dormancy
TK Wood, SJ Knabel, BW Kwan - Applied and environmental …, 2013 - Am Soc Microbiol
Bacterial cells may escape the effects of antibiotics without undergoing genetic change;
these cells are known as persisters. Unlike resistant cells that grow in the presence of …
these cells are known as persisters. Unlike resistant cells that grow in the presence of …
Biofilm infections, their resilience to therapy and innovative treatment strategies
U Römling, C Balsalobre - Journal of internal medicine, 2012 - Wiley Online Library
Biofilm formation of microorganisms causes persistent tissue and foreign body infections
resistant to treatment with antimicrobial agents. Up to 80% of human bacterial infections are …
resistant to treatment with antimicrobial agents. Up to 80% of human bacterial infections are …
Regulation of bacterial virulence by Csr (Rsm) systems
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …
and in specialized host niches. This ability requires their metabolism, physiology, and …