The development of personalized medicine is a primary objective of the medical community
and increasingly also of funding and registration agencies. Modeling is generally perceived …

Seaweeds are sources of biomolecules with biological activities and pharmacological
potential–for example, lectins, a group of proteins that can bind reversibly to carbohydrates …

As populations worldwide show increasing levels of stress, understanding emerging links
among stress, inflammation, cognition, and behavior is vital to human and planetary health …

Background Inflammation is a highly complex biological response evoked by many stimuli. A
persistent challenge in modeling this dynamic process has been the (nonlinear) nature of …

Systems biology aims to understand the nonlinear interactions of multiple biomolecular
components that characterize a living organism. One important aspect of systems biology …

Inflammation is part of a complex physiological response to harmful stimuli and pathogenic
stress. The five components of the Nuclear Factor κB (NF-κB) family are prominent mediators …

NF-κB is a key transcription factor that regulates innate immune response. Its activity is
tightly controlled by numerous feedback loops, including two negative loops mediated by NF …

Background CCAAT enhancer–binding protein epsilon (C/EBPε) is a transcription factor
involved in late myeloid lineage differentiation and cellular function. The only previously …

Elucidation of pathogenicity mechanisms of the most important human-pathogenic fungi,
Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the …

Achieving perfect skin regeneration after wounding remains challenging because of the lack
of fundamental understanding of the harmonious interplay among different cell types …