The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease.
The Janus kinase-signal transducer and activator of transcription pathway plays a major role …

Introduction Deucravacitinib, a novel, oral, selective inhibitor of tyrosine kinase 2 (TYK2)
signaling, acts via an allosteric mechanism by binding to the enzyme's regulatory domain …

Numerous chronic inflammatory skin diseases are associated with the release of
proinflammatory cytokines, which act via the intracellular JAK‐STAT pathway. JAK inhibitors …

Psoriasis is a frequent, chronic disease characterized by cutaneous inflammatory plaques
and/or arthritis. It may be associated with few other diseases, mainly Crohn's disease and …

The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate
the intracellular signaling of cytokines in a wide spectrum of cellular processes. They …

Highlights•Innate immune signaling components (RIPK1, TAK1 and ZBP1) are critical
regulators of inflammation and programmed cell death.•Innate signaling connected with …

Conventional systemic and biologic agents are the mainstay of inflammatory bowel disease
(IBD) management; however, many of these agents are associated with loss of clinical …

Psoriasis and inflammatory bowel disease (IBD) are immune‐mediated diseases occurring
in barrier organs whose main task is to protect the organism from attack. These disorders are …

Background Psoriasis is an autoimmune/inflammatory disorder primarily affecting the skin.
Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately …