Sex differences occur in most non-communicable diseases, including metabolic diseases,
hypertension, cardiovascular disease, psychiatric and neurological disorders and cancer. In …

Early stages of mammalian embryonic development are now known to be very sensitive to
their microenvironment, with long term effects on fetal, postnatal, and adult health, thus …

This review article outlines epidemiologic studies that support the hypothesis that maternal
environment (including early nutrition) plays a seminal role in determining the offspring's …

The preconceptual, intrauterine, and early life environments can have a profound and long-
lasting impact on the developmental trajectories and health outcomes of the offspring. Given …

In spite of improving life expectancy over the course of the previous century, the health of the
US population is now worsening. Recent increasing rates of type 2 diabetes, obesity and …

Aim Obesity at the start of pregnancy has been rising worldwide, increasing the risk of
maternal complications. We reviewed the independent effects of maternal obesity during …

Human and animal studies have revealed a strong association between periconceptional
environmental factors, such as poor maternal diet, and an increased propensity for …

A significant number of multiple pregnancies and births worldwide continue to occur
following treatment with Assisted Reproductive Technologies (ARTs). Whilst efforts have …

Fetal programming of metabolic diseases is now a well established concept. The scope of
the Developmental Origins of Health and Disease has, however, widened and led to the …

The pig oocyte maturation protocol differs from other mammalian species due to
dependence on follicular fluid (FF) supplementation. One of the most abundant components …