Emerging roles for serotonin in regulating metabolism: new implications for an ancient molecule
Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …
[HTML][HTML] Mitochondrial proton leaks and uncoupling proteins
DG Nicholls - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2021 - Elsevier
Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …
(UCP1), which provides a carefully regulated proton re-entry pathway across the …
Adipose tissue macrophages and their role in obesity-associated insulin resistance: an overview of the complex dynamics at play
S Guria, A Hoory, S Das, D Chattopadhyay… - Bioscience …, 2023 - portlandpress.com
Obesity, a major global health concern, is characterized by serious imbalance between
energy intake and expenditure leading to excess accumulation of fat in adipose tissue (AT) …
energy intake and expenditure leading to excess accumulation of fat in adipose tissue (AT) …
Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced …
Q Ma, X Zhou, L Hu, J Chen, J Zhu, A Shan - Food & function, 2020 - pubs.rsc.org
Branched chain amino acids (BCAAs), especially leucine (Leu), have been reported to
decrease fat deposition. However, extensive studies have not been conducted to determine …
decrease fat deposition. However, extensive studies have not been conducted to determine …
[HTML][HTML] The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
X Yin, Y Chen, R Ruze, R Xu, J Song… - Signal Transduction and …, 2022 - nature.com
The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …
Gut microbiota mediates the effects of curcumin on enhancing Ucp1-dependent thermogenesis and improving high-fat diet-induced obesity
Z Han, L Yao, Y Zhong, Y Xiao, J Gao, Z Zheng… - Food & function, 2021 - pubs.rsc.org
Due to extremely poor systemic bioavailability, the mechanism by which curcumin increases
energy expenditure remains unelucidated. Accumulating evidence suggests a strong …
energy expenditure remains unelucidated. Accumulating evidence suggests a strong …
[HTML][HTML] Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder
Mitochondrial uncoupling proteins (UCP) are a part of the large family of mitochondrial
solute carriers (SLC25s), concentrated in the inner mitochondrial membrane that carries …
solute carriers (SLC25s), concentrated in the inner mitochondrial membrane that carries …
CRISPRa‐based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning
H Zhu, D Liu, M Sui, M Zhou, B Wang… - Clinical and …, 2023 - Wiley Online Library
Background Skeletal muscle‐secreted myokines widely participate in lipids metabolism
through autocrine, paracrine and endocrine actions. The myokines represented by FGF21 …
through autocrine, paracrine and endocrine actions. The myokines represented by FGF21 …
Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression
MicroRNAs (miRNAs) have been implicated in oxidative metabolism and brown/beige
adipocyte identity. Here, we tested whether widespread changes in miRNA expression …
adipocyte identity. Here, we tested whether widespread changes in miRNA expression …
Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and …
M Reyad-ul-Ferdous, Y Song - International Journal of Biological …, 2022 - Elsevier
Background Obesity, fatty liver, type 2 diabetes, and Non-alcoholic fatty liver disease
(NAFLD) are all metabolic diseases caused by excess food consumption. Existing drug …
(NAFLD) are all metabolic diseases caused by excess food consumption. Existing drug …