Clinical significance of microbial infection and adaptation in cystic fibrosis

AR Hauser, M Jain, M Bar-Meir… - Clinical microbiology …, 2011 - Am Soc Microbiol
SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …

Pseudomonas aeruginosa biofilm infections: From molecular biofilm biology to new treatment possibilities

T Tolker‐Nielsen - Apmis, 2014 - Wiley Online Library
Bacteria in natural, industrial and clinical settings predominantly live in biofilms, ie, sessile
structured microbial communities encased in self‐produced extracellular matrix material …

Genome Diversity of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients and the Hospital Environment

S Finnan, JP Morrissey, F O'gara… - Journal of clinical …, 2004 - Am Soc Microbiol
Pseudomonas aeruginosa is a gram-negative rod that is ubiquitous in nature. P. aeruginosa
is also the quintessential opportunistic pathogen, causing a wide variety of infections in …

Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans

G McAlester, F O'Gara… - Journal of medical …, 2008 - microbiologyresearch.org
Pseudomonas aeruginosa causes infections in a wide variety of hosts and is the leading
cause of mortality in cystic fibrosis (CF) patients. Although most clinical isolates of P …

Detection of a Widespread Clone of Pseudomonas aeruginosa in a Pediatric Cystic Fibrosis Clinic

DS Armstrong, GM Nixon, R Carzino… - American journal of …, 2002 - atsjournals.org
Cross-infection by Pseudomonas aeruginosa between unrelated patients with cystic fibrosis
(CF) is believed to be uncommon. After detecting a genotypically identical strain of P …

Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans

LJ Holcombe, G McAlester, CA Munro… - …, 2010 - microbiologyresearch.org
Signal-mediated interactions between the human opportunistic pathogens Pseudomonas
aeruginosa and Candida albicans affect virulence traits in both organisms. Phenotypic …

Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS

AW Maresso, MR Baldwin, JT Barbieri - Journal of Biological Chemistry, 2004 - ASBMB
Pseudomonas aeruginosa ExoS is a bifunctional type III-secreted cytotoxin. The N terminus
(amino acids 96–233) encodes a GTPase-activating protein activity, whereas the C terminus …

C-type natriuretic peptide modulates quorum sensing molecule and toxin production in Pseudomonas aeruginosa

AS Blier, W Veron, A Bazire, E Gerault… - …, 2011 - microbiologyresearch.org
Pseudomonas aeruginosa coordinates its virulence expression and establishment in the
host in response to modification of its environment. During the infectious process, bacteria …

Defining routes of airborne transmission of Pseudomonas aeruginosa in people with cystic fibrosis

IJ Clifton, DG Peckham - Expert review of respiratory medicine, 2010 - Taylor & Francis
Pseudomonas aeruginosa is a common and important pathogen in people with cystic
fibrosis (CF). With the advent of modern genotyping, a number of clonal strains of P …

Respiratory pathogens adopt a chronic lifestyle in response to bile

FJ Reen, DF Woods, MJ Mooij, C Adams, F O'gara - 2012 - journals.plos.org
Chronic respiratory infections are a major cause of morbidity and mortality, most particularly
in Cystic Fibrosis (CF) patients. The recent finding that gastro-esophageal reflux (GER) …