[HTML][HTML] Therapies for allergic inflammation: refining strategies to induce tolerance

CA Akdis - Nature medicine, 2012 - nature.com
Current therapies for asthma and allergy are relatively safe and effective at controlling
symptoms but do not change the chronic course of disease. There is no established method …

The role of the T cell in asthma

DS Robinson - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
Since the initial detection of TH2 cytokines in asthmatic airways, our understanding of the
complexity of T-cell subtypes and flexibility and of the potential role of airway structural cells …

Allergen immunotherapy: a practice parameter third update

L Cox, H Nelson, R Lockey, C Calabria… - Journal of Allergy and …, 2011 - jacionline.org
This document builds on the previous Joint Task Force document ''Allergen immunotherapy:
a practice parameter second update''published in the Journal of Allergy and Clinical …

Thiazolidine-2, 4-diones: Progress towards multifarious applications

VS Jain, DK Vora, CS Ramaa - Bioorganic & medicinal chemistry, 2013 - Elsevier
The promising activity shown by compounds containing thiazolidine-2, 4-dione nucleus in
numerous categories such as anti-hyperglycaemics, aldose reductase inhibitors, anti …

Therapeutic manipulation of immune tolerance in allergic disease

M Akdis, CA Akdis - Nature reviews drug discovery, 2009 - nature.com
Immune tolerance—the adaptation of the immune system to external antigens or allergens—
might be therapeutically manipulated to restore normal immunity in conditions such as …

Problematic severe asthma in children, not one problem but many: a GA2LEN initiative

G Hedlin, A Bush, KL Carlsen… - European …, 2010 - Eur Respiratory Soc
Although most children with asthma are easy to treat with low doses of safe medications,
many remain symptomatic despite every therapeutic effort. The nomenclature regarding this …

Toll-like receptor 7–triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma

C Xirakia, O Koltsida, A Stavropoulos… - American journal of …, 2010 - atsjournals.org
Rationale: Toll-like receptor (TLR) 7/8 ligands are promising candidate drugs for the
treatment of allergic asthma and rhinitis. Although their clinical application depends on the …

The paradigm of cytokine networks in allergic airway inflammation

R Pawankar, M Hayashi, S Yamanishi… - Current opinion in …, 2015 - journals.lww.com
The paradigm of cytokine networks in allergic airway inflamm... : Current Opinion in Allergy and
Clinical Immunology The paradigm of cytokine networks in allergic airway inflammation …

Therapeutic approach of anaphylaxis

LK Tanno, A Alvarez-Perea… - Current Opinion in Allergy …, 2019 - journals.lww.com
Adrenaline (epinephrine) is still the first-line treatment for any type of anaphylaxis and is
recognized as the only medication documented to prevent hospitalizations, hypoxic …

[图书][B] The use of in vitro 3D cell models in drug development for respiratory diseases

S Huang, L Wiszniewski, S Constant - 2011 - books.google.com
In a certain way, drug developers are like the blind men in the well-known tale of “THE
BLIND MEN AND THE ELEPHANT”, who believe the elephant to be like a water spout, a fan …