Precision cancer medicine is a multidisciplinary team effort that requires involvement and
commitment of many stakeholders including the society at large. Building on the success of …

Sarcoma subtype classification is currently mainly based upon histopathological
morphology. Molecular analyses have emerged as an efficient addition to the diagnostic …

Clinical whole-genome sequencing (WGS) has been shown to deliver potential benefits to
children with cancer and to alter treatment in high-risk patient groups. It remains unknown …

Patient Derived Organoids (PDOs) emerged as the best technology to develop ex vivo tumor
avatars. Whether drug testing on PDOs to identify efficient therapies will bring clinical utility …

Introduction The suitability of whole-genome sequencing (WGS) as the sole method to
detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) …

Summary The Long-Read Personalized OncoGenomics (POG) dataset comprises a cohort
of 189 patient tumors and 41 matched normal samples sequenced using the Oxford …

Tumor type guides clinical treatment decisions in cancer, but histology-based diagnosis
remains challenging. Genomic alterations are highly diagnostic of tumor type, and tumor …

Two decades after the genomics revolution, oncology is rapidly transforming into a genome-
driven discipline, yet routine cancer diagnostics is still mainly microscopy based, except for …

Genetic testing has been applied for decades in clinical routine diagnostics of hematological
malignancies to improve disease (sub) classification, prognostication, patient management …

The continuing evolution of treatment options in thoracic oncology requires the pathologist to
regularly update diagnostic algorithms for management of tumor samples. It is essential to …