The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy

F Xie, X Zhou, M Fang, H Li, P Su, Y Tu… - Advanced …, 2019 - Wiley Online Library
Extracellular vesicles (EVs) are secreted by almost all cells. They contain proteins, lipids,
and nucleic acids which are delivered from the parent cells to the recipient cells. Thereby …

Routes and mechanisms of extracellular vesicle uptake

LA Mulcahy, RC Pink, DRF Carter - Journal of extracellular …, 2014 - Taylor & Francis
Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

Inside (sight) of tiny communicator: exosome biogenesis, secretion, and uptake

AS Jadli, N Ballasy, P Edalat, VB Patel - Molecular and cellular …, 2020 - Springer
Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from
reticulocytes, exosomes recently gained scientific attention due to its role in intercellular …

Free energies of membrane stalk formation from a lipidomics perspective

CS Poojari, KC Scherer, JS Hub - Nature communications, 2021 - nature.com
Many biological membranes are asymmetric and exhibit complex lipid composition,
comprising hundreds of distinct chemical species. Identifying the biological function and …

Can we beat the biotin–avidin pair?: cucurbit [7] uril-based ultrahigh affinity host–guest complexes and their applications

D Shetty, JK Khedkar, KM Park, K Kim - Chemical Society Reviews, 2015 - pubs.rsc.org
The design of synthetic, monovalent host–guest molecular recognition pairs is still
challenging and of particular interest to inquire into the limits of the affinity that can be …

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

Y Wei, D Wang, F Jin, Z Bian, L Li, H Liang, M Li… - Nature …, 2017 - nature.com
Tumour cells secrete exosomes that are involved in the remodelling of the tumour–stromal
environment and promoting malignancy. The mechanisms governing tumour exosome …

Peptide antimicrobial agents

H Jenssen, P Hamill, REW Hancock - Clinical microbiology …, 2006 - Am Soc Microbiol
Antimicrobial host defense peptides are produced by all complex organisms as well as
some microbes and have diverse and complex antimicrobial activities. Collectively these …

The cell biology of neurogenesis

M Götz, WB Huttner - Nature reviews Molecular cell biology, 2005 - nature.com
During the development of the mammalian central nervous system, neural stem cells and
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …

Cholesterol in brain disease: sometimes determinant and frequently implicated

MG Martín, F Pfrieger, CG Dotti - EMBO reports, 2014 - embopress.org
Cholesterol is essential for neuronal physiology, both during development and in the adult
life: as a major component of cell membranes and precursor of steroid hormones, it …