Signaling pathways in inflammation and anti-inflammatory therapies

YT Yeung, F Aziz, A Guerrero-Castilla… - Current …, 2018 - ingentaconnect.com
During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Inflammation and cancer: advances and new agents

SM Crusz, FR Balkwill - Nature reviews Clinical oncology, 2015 - nature.com
Tumour-promoting inflammation is considered one of the enabling characteristics of cancer
development. Chronic inflammatory disease increases the risk of some cancers, and strong …

Cancer-related inflammation and treatment effectiveness

CI Diakos, KA Charles, DC McMillan… - The Lancet …, 2014 - thelancet.com
Inflammation is a recognised hallmark of cancer that substantially contributes to the
development and progression of malignancies. In established cancers, there is increasing …

[HTML][HTML] Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

R Zhang, F Qi, F Zhao, G Li, S Shao, X Zhang… - Cell death & …, 2019 - nature.com
Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are
important components of the tumor microenvironment, which have been reported to localize …

A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy

Q Qi, L Zhuang, Y Shen, Y Geng, S Yu, H Chen, L Liu… - Cancer, 2016 - Wiley Online Library
BACKGROUND Predicting survival is uniquely difficult in patients with pancreatic cancer
who receive chemotherapy. The authors developed a systemic inflammation response index …

Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment

SJ Carter, RS Tattersall, AV Ramanan - Rheumatology, 2019 - academic.oup.com
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which if not
promptly treated, can lead rapidly to critical illness and death. HLH is termed macrophage …

Thymoquinone: potential cure for inflammatory disorders and cancer

CC Woo, AP Kumar, G Sethi, KHB Tan - Biochemical pharmacology, 2012 - Elsevier
Thymoquinone is an active ingredient isolated from Nigella sativa and has been
investigated for its anti-oxidant, anti-inflammatory and anticancer activities in both in vitro …

[HTML][HTML] HCC and angiogenesis: possible targets and future directions

AX Zhu, DG Duda, DV Sahani, RK Jain - Nature reviews Clinical …, 2011 - nature.com
Hepatocellular carcinoma (HCC), the most common primary liver tumor, is notoriously
resistant to systemic therapies, and often recurs even after aggressive local therapies. HCCs …

IL-8 signaling plays a critical role in the epithelial–mesenchymal transition of human carcinoma cells

RI Fernando, MD Castillo, M Litzinger, DH Hamilton… - Cancer research, 2011 - AACR
The switch of tumor cells from an epithelial to a mesenchymal-like phenotype [designated as
epithelial-to-mesenchymal transition (EMT)] is known to induce tumor cell motility and …

Kaempferol, a potential cytostatic and cure for inflammatory disorders

P Rajendran, T Rengarajan, N Nandakumar… - European journal of …, 2014 - Elsevier
Abstract Kaempferol (3, 5, 7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a
flavonoid found in many edible plants (eg, tea, broccoli, cabbage, kale, beans, endive, leek …