Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people

YN Koyanagi, M Nakatochi, S Namba, I Oze… - Science …, 2024 - science.org
An East Asian–specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G> A) is the
major genetic determinant of alcohol consumption. We performed an rs671 genotype …

Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma

Y Aftabi, N Gilani, A Ansarin… - Canadian Journal of …, 2023 - cdnsciencepub.com
The nitric oxide (NO) pathway contributes to the pathogeneses of metabolic syndrome
(MetS) and asthma. NOS2 encodes inducible-NO synthase, which is an important enzyme of …

SNPs in FAM13A and IL2RB genes are associated with FeNO in adult subjects with asthma

S Accordini, V Lando, L Calciano… - Journal of Breath …, 2023 - iopscience.iop.org
Nitric oxide has different roles in asthma as both an endogenous modulator of airway
function and a pro-inflammatory mediator. Fractional exhaled nitric oxide (FeNO) is a …

Fractional exhaled nitric oxide distribution and its relevant factors in the general adult population and its healthy subpopulation

M Yamada, M Takase, K Nakaya, T Nakamura… - Journal of Allergy and …, 2024 - Elsevier
Background Measurement of fractional exhaled nitric oxide (F eno) has been used in the
diagnosis and management of asthma. Understanding the distribution of F eno in a larger …

Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort …

M Takase, M Yamada, T Nakamura… - Journal of …, 2023 - journals.lww.com
Background: Although several studies have shown an inverse association between lung
function and hypertension, few studies have examined the association between lung …

An observational analysis on the influence of parental allergic rhinitis, asthma and smoking on exhaled nitric oxide in offspring

S Zaigham, RJ Bertelsen, SC Dharmage, V Schlünssen… - Nitric Oxide, 2024 - Elsevier
Background Parental allergic diseases and smoking influence respiratory disease in the
offspring but it is not known whether they influence fractional exhaled nitric oxide (FeNO) in …

Associations between birth weight and lung function in a Japanese adult population: The tohoku medical megabank community-based cohort study

T Ohe, M Yamada, A Hozawa, N Nakaya… - Respiratory …, 2023 - Elsevier
Background Birth weight, as a measure of intrauterine growth, is commonly used in
epidemiological studies and is reported to be associated with adult lung function. However …

Carotid intima media thickness and risk factor for atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study

M Takase, N Nakaya, T Nakamura… - … of Atherosclerosis and …, 2023 - jstage.jst.go.jp
Aim: We examined the association between the carotid intima medica thickness (cIMT) and
risk factors for atherosclerosis based on the Japan Atherosclerosis Society 2022 …

The role of ferroptosis-related genes in airway epithelial cells of asthmatic patients based on bioinformatics

Y Zheng, J Fan, X Jiang - Medicine, 2023 - journals.lww.com
It has been reported that airway epithelial cells and ferroptosis have certain effect on
asthma. However, the action mechanism of ferroptosis-related genes in airway epithelial …

Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based …

M Takase, N Nakaya, T Nakamura… - … of Atherosclerosis and …, 2023 - jstage.jst.go.jp
Aim: The influence of family history of diabetes, probably reflecting genetic and lifestyle
factors, on the association of combined genetic and lifestyle risks with diabetes is unknown …