Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of
the most versatile cytokine signalling pathways in metazoan biology, the transforming …

In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase
progression and escape from immune surveillance. Here we show that MYC in PDAC cells …

Urological cancers, including prostate, bladder, and renal cancers, are significant causes of
death and negatively impact the quality of life for patients. The development and progression …

Backgound Colorectal cancer (CRC) is a complex, multistep disease that arises from the
interplay genetic mutations and epigenetic alterations. The histone H3K36 …

Inactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly
affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the …

Oral squamous cell carcinoma (OSCC) is a malignant neoplasm with high mortality and
morbidity. The role of circRNA and its molecular mechanism in OSCC remains largely …

Simple Summary Nidogen1 (NID1) is a component of the extracellular matrix and basement
membranes. NID1 represents a linker between laminins, collagens, proteoglycans and cell …

Excessive fructose diet is closely associated with colorectal cancer (CRC) progression.
Nevertheless, fructose's specific function and precise mechanism in colorectal cancer liver …

TGF-β signaling plays an essential role in colorectal cancer (CRC) progression. Patients
frequently suffer from mutations in the TGFBR2 gene or deletions of SMAD4. These …