In this study, we describe the generation and partial characterization of Krüppel-like zinc
finger protein Glis3 mutant (Glis3zf/zf) mice. These mice display abnormalities very similar to …

Mutations in the PKHD1 gene, which encodes fibrocystin, cause autosomal recessive
polycystic kidney disease (ARPKD). Unfortunately, the lack of specific antibodies to the …

Autosomal recessive polycystic kidney disease (ARPKD) is a severe, typically early onset
form of renal cystic disease. The care of ARPKD patients has traditionally been the purview …

Autosomal recessive polycystic kidney disease is a hereditary fibrocystic disease that
involves the kidneys and the biliary tract. Mutations in the PKHD1 gene are responsible for …

Renal cystic diseases encompass a broad group of disorders with variable phenotypic
expression. Cystic disorders can present during infancy, childhood, or adulthood. Often, but …

Autosomal recessive polycystic kidney disease (OMIM 263200) is a serious condition of the
kidney and liver caused by mutations in a single gene, PKHD1. This gene encodes …

Abstract Background/Methods: We have examined the hypothesis that cyst formation is key
in the pathogenesis of cardiovascular disease in a Lewis polycystic kidney (LPK) model of …

Members of the epidermal growth factor (EGF) family bind to ErbB (EGFR) family receptors
which play an important role in the regulation of various fundamental cell processes …

Polycystic kidney disease (PKD) is a diverse group of human monogenic lethal conditions
inherited as autosomal dominant (AD) or recessive (AR) traits. Recent development of …

Autosomal recessive polycystic kidney disease (ARPKD) is a rare but highly relevant
disorder in pediatric nephrology. This genetic disease is mainly caused by variants in the …