[HTML][HTML] Genetics of hypertension: from experimental animals to humans
Essential hypertension affects 20 to 30% of the population worldwide and contributes
significantly to cardiovascular mortality and morbidity. Heridability of blood pressure is …
significantly to cardiovascular mortality and morbidity. Heridability of blood pressure is …
ET‐1 actions in the kidney: evidence for sex differences
W Kittikulsuth, JC Sullivan… - British journal of …, 2013 - Wiley Online Library
Hypertension and chronic kidney disease are more common in men than in premenopausal
women at the same age. In animal models, females are relatively protected against genetic …
women at the same age. In animal models, females are relatively protected against genetic …
[HTML][HTML] A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese …
Y Takahashi, K Yamazaki, Y Kamatani, M Kubo… - Scientific Reports, 2021 - nature.com
Numerous genetic variants associated with hypertension and blood pressure are known, but
there is a paucity of evidence from genetic studies of resistant hypertension, especially in …
there is a paucity of evidence from genetic studies of resistant hypertension, especially in …
Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts
KW Hong, MJ Go, HS Jin, JE Lim, JY Lee… - Journal of human …, 2010 - nature.com
Blood pressure, one of the important vital signs, is affected by multiple genetic and
environmental factors. Recently, several genome-wide association (GWA) studies have …
environmental factors. Recently, several genome-wide association (GWA) studies have …
[HTML][HTML] Resveratrol arrests and regresses the development of pressure overload-but not volume overload-induced cardiac hypertrophy in rats
P Wojciechowski, D Juric, XL Louis, SJ Thandapilly… - The Journal of …, 2010 - Elsevier
Cardiac hypertrophy is a compensatory enlargement of the heart due to either volume
overload (VO) and/or pressure overload (PO) that develops into heart failure if left untreated …
overload (VO) and/or pressure overload (PO) that develops into heart failure if left untreated …
Genetic variations in CYP17A1, CACNB2 and PLEKHA7 are associated with blood pressure and/or hypertension in She ethnic minority of China
Y Lin, X Lai, B Chen, Y Xu, B Huang, Z Chen, S Zhu… - Atherosclerosis, 2011 - Elsevier
OBJECTIVES: Two large-scale genome-wide association studies (GWAs) have identified
multiple variants associated with blood pressure (BP) or hypertension. The present study …
multiple variants associated with blood pressure (BP) or hypertension. The present study …
[HTML][HTML] Genome-wide study of resistant hypertension identified from electronic health records
Resistant hypertension is defined as high blood pressure that remains above treatment
goals in spite of the concurrent use of three antihypertensive agents from different classes …
goals in spite of the concurrent use of three antihypertensive agents from different classes …
A potential regulatory single nucleotide polymorphism in the promoter of the Klotho gene may be associated with essential hypertension in the Chinese Han …
HL Wang, Q Xu, Z Wang, YH Zhang, LY Si, XJ Li… - Clinica chimica acta, 2010 - Elsevier
BACKGROUND: Mice with defects in the Klotho gene exhibit multiple aging phenotypes
including arteriosclerosis. We hypothesised that the G-395A polymorphism in the promoter …
including arteriosclerosis. We hypothesised that the G-395A polymorphism in the promoter …
[HTML][HTML] Lower ADD1 Gene Promoter DNA Methylation Increases the Risk of Essential Hypertension
LN Zhang, PP Liu, L Wang, F Yuan, L Xu, Y Xin, LJ Fei… - PloS one, 2013 - journals.plos.org
The goal of our study is to investigate the contribution of promoter DNA methylation of α-
adducin (ADD1) gene to the risk of essential hypertension (EH). Using the bisulphite …
adducin (ADD1) gene to the risk of essential hypertension (EH). Using the bisulphite …
Association of ACE gene A2350G and I/D polymorphisms with essential hypertension in the northernmost province of China
F Sun, N He, K Zhang, N Wu, J Zhao… - Clinical and experimental …, 2018 - Taylor & Francis
Angiotensin converting enzyme (ACE) gene, as a strong candidate gene for essential
hypertension (EH), has been extensively studied. In this study, we carried out a population …
hypertension (EH), has been extensively studied. In this study, we carried out a population …