Essential hypertension affects 20 to 30% of the population worldwide and contributes
significantly to cardiovascular mortality and morbidity. Heridability of blood pressure is …

Hypertension and chronic kidney disease are more common in men than in premenopausal
women at the same age. In animal models, females are relatively protected against genetic …

Numerous genetic variants associated with hypertension and blood pressure are known, but
there is a paucity of evidence from genetic studies of resistant hypertension, especially in …

Blood pressure, one of the important vital signs, is affected by multiple genetic and
environmental factors. Recently, several genome-wide association (GWA) studies have …

Cardiac hypertrophy is a compensatory enlargement of the heart due to either volume
overload (VO) and/or pressure overload (PO) that develops into heart failure if left untreated …

OBJECTIVES: Two large-scale genome-wide association studies (GWAs) have identified
multiple variants associated with blood pressure (BP) or hypertension. The present study …

Resistant hypertension is defined as high blood pressure that remains above treatment
goals in spite of the concurrent use of three antihypertensive agents from different classes …

BACKGROUND: Mice with defects in the Klotho gene exhibit multiple aging phenotypes
including arteriosclerosis. We hypothesised that the G-395A polymorphism in the promoter …

The goal of our study is to investigate the contribution of promoter DNA methylation of α-
adducin (ADD1) gene to the risk of essential hypertension (EH). Using the bisulphite …

Angiotensin converting enzyme (ACE) gene, as a strong candidate gene for essential
hypertension (EH), has been extensively studied. In this study, we carried out a population …