Antigen-specificity measurements are the key to understanding T cell responses

R Tippalagama, LY Chihab, K Kearns, S Lewis… - Frontiers in …, 2023 - frontiersin.org
Antigen-specific T cells play a central role in the adaptive immune response and come in a
wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in …

Multiparameter immunoprofiling for the diagnosis and differentiation of progressive versus nonprogressive nontuberculous mycobacterial lung disease–A pilot study

PK Marty, B Pathakumari, TM Cox, VP Van Keulen… - Plos one, 2024 - journals.plos.org
Clinical prediction of nontuberculous mycobacteria lung disease (NTM-LD) progression
remains challenging. We aimed to evaluate antigen-specific immunoprofiling utilizing flow …

The MegaPool Approach to Characterize Adaptive CD4+ and CD8+ T Cell Responses

R da Silva Antunes, D Weiskopf, J Sidney… - Current …, 2023 - Wiley Online Library
Epitopes recognized by T cells are a collection of short peptide fragments derived from
specific antigens or proteins. Immunological research to study T cell responses is hindered …

Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection

IR Cinco, EG Napier, NS Rhoades, MH Davies… - Mbio, 2024 - Am Soc Microbiol
Nontuberculous mycobacteria (NTM) are environmentally ubiquitous organisms that
predominately cause NTM pulmonary disease (NTMPD) in individuals over the age of 65 …

New genetic biomarkers from transcriptome RNA-sequencing for Mycobacterium tuberculosis complex and Mycobacterium avium complex infections by …

Q Jia, Y Wu, Y Huang, X Bai - Scientific Reports, 2024 - nature.com
The study aims to accurately identify differentially expressed genes (DEGs) and biological
pathways in mycobacterial infections through bioinformatics for deeper disease …

E3 ubiquitin ligase CBLB regulates innate immune responses and bacterial dissemination during nontuberculous mycobacteria infection

J Sharma, S Mudalagiriyappa… - Journal of Leukocyte …, 2024 - academic.oup.com
Nontuberculous mycobacteria (NTM) are emerging opportunistic pathogens causing
pulmonary infection to fatal disseminated disease. NTM infections are steadily increasing in …

Building a model for the differential diagnosis of non-tuberculous mycobacterial lung disease and pulmonary tuberculosis: A case-control study based on …

Q Liu, X Pan, H An, J Du, X Li, W Sun, Y Gao… - International …, 2023 - Elsevier
Background Although the incidence of non-tuberculous mycobacterial pulmonary disease
(NTM-PD) is increasing annually, it is easily misdiagnosed as pulmonary tuberculosis (PTB) …

[HTML][HTML] Attenuated tuberculin skin test responses associated with Mycobacterium intracellulare sputum colonization in an adolescent TB prevalence survey in …

LN Njagi, G Kaguthi, JO Mecha, TR Hawn, V Nduba - Tuberculosis, 2024 - Elsevier
Abstract Introduction Exposure to Non-tuberculous Mycobacteria (NTM) varies regionally
and may partly explain the disparate outcomes of BCG vaccination and tuberculosis (TB) …

少见非结核分枝杆菌病药物治疗新方案的研究进展

胡毅, 唐莉歆, 李同心, 唐神结, 杨松 - 新发传染病电子杂志, 2023 - xfcrb2020.com
非结核分枝杆菌病呈全球增长之势, 仍然是全球公共卫生问题之一, 其发病率,
病死率和经济成本仍居高不下. 分枝杆菌对大多数抗生素具有固有耐药性, 治疗难度较大 …

Impact of aging on the immunological and microbial landscape of the lung during non-tuberculous mycobacterial infection

IR Cinco, NS Rhoades, EG Napier, M Davies… - bioRxiv, 2023 - biorxiv.org
Nontuberculous mycobacteria (NTM) are environmentally ubiquitous and predominately
cause pulmonary disease (NTMPD). The incidence of NTMPD has steadily increased and is …