Background Accumulated evidence has proved that both neuroinflammation and
neuroprotection existing at the stage of mild cognitive impairment (MCI) may mediate its …

Stressful life experiences are associated with the development of neuropsychiatric disorders
like depression. Emerging evidence indicates that microglia, the specialized resident …

In the medial prefrontal cortex (PFC), chronic stress reduces synaptic expression of
glutamate receptors, leading to decreased excitatory signaling from layer V pyramidal …

Depression is a serious mental illness, mainly characterized as large mood swings and
sleep, diet, and cognitive function disorders. NLPR3, one of the inflammasomes that can be …

Microglia are the primary immunocompetent cells that protect the brain from environmental
stressors, but can also be driven to release pro-inflammatory cytokines and induce a …

Depression is a prevalent psychiatric disorder. Microglial state transition has been found in
many neurological disorders including depression. Gypenosides (Gypenosides I-LXXVIII …

Electroconvulsive therapy (ECT) has been effectively used for almost a century, but its
mechanisms of action remain poorly understood. Two primary hypotheses have been …

Circadian rhythms are involved in the regulation of many aspects of the body, including cell
function, physical activity and disease. Circadian disturbance often predates the typical …

Depression is one of the most common mental disorders, which can lead to a variety of
emotional problems and even suicide at its worst. As this neuropsychiatric disorder causes …

There is much excitement surrounding recent research of promising, mechanistically novel
psychotherapeutics–psychedelic, anesthetic, and dissociative agents–as they have …