[HTML][HTML] Obesity, inflammation, and immune system in osteoarthritis
U Nedunchezhiyan, I Varughese, ARJ Sun… - Frontiers in …, 2022 - frontiersin.org
Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …
[HTML][HTML] Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …
[HTML][HTML] p16 (Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli
Constitutive p16 Ink4a expression, along with senescence-associated β-galactosidase
(SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports …
(SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports …
Ferroptosis-strengthened metabolic and inflammatory regulation of tumor-associated macrophages provokes potent tumoricidal activities
Modulation of tumor-associated macrophages (TAMs) holds promise for cancer treatment,
mainly relying on M1 signaling activation and pro-inflammatory promotion. Nevertheless, the …
mainly relying on M1 signaling activation and pro-inflammatory promotion. Nevertheless, the …
[HTML][HTML] Macrophages and bone inflammation
Q Gu, H Yang, Q Shi - Journal of orthopaedic translation, 2017 - Elsevier
Bone metabolism is tightly regulated by the immune system. Accelerated bone destruction is
observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle …
observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle …
[HTML][HTML] Macrophages in osteoarthritis: pathophysiology and therapeutics
Y Chen, W Jiang, H Yong, M He, Y Yang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain …
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain …
[HTML][HTML] Communications between bone marrow macrophages and bone cells in bone remodeling
K Chen, Y Jiao, L Liu, M Huang, C He, W He… - Frontiers in Cell and …, 2020 - frontiersin.org
The mammalian skeleton is a metabolically active organ that continuously undergoes bone
remodeling, a process of tightly coupled bone resorption and formation throughout life …
remodeling, a process of tightly coupled bone resorption and formation throughout life …
Mechanism of iron oxide-induced macrophage activation: the impact of composition and the underlying signaling pathway
Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing
tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing …
tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing …
[HTML][HTML] Cell interplay in osteoarthritis
Z Li, Z Huang, L Bai - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Osteoarthritis (OA) is a common chronic disease and a significant health concern that needs
to be urgently solved. OA affects the cartilage and entire joint tissues, including the …
to be urgently solved. OA affects the cartilage and entire joint tissues, including the …
[HTML][HTML] High-molecular-weight hyaluronic acid inhibits IL-1β-induced synovial inflammation and macrophage polarization through the GRP78-NF-κB signaling …
CH Lee, CF Chiang, FC Kuo, SC Su, CL Huang… - International journal of …, 2021 - mdpi.com
Recent evidence has suggested that synovial inflammation and macrophage polarization
were involved in the pathogenesis of osteoarthritis (OA). Additionally, high-molecular-weight …
were involved in the pathogenesis of osteoarthritis (OA). Additionally, high-molecular-weight …