Disease-modifying anti-asthmatic drugs

M Lommatzsch, GG Brusselle, GW Canonica… - The Lancet, 2022 - thelancet.com
Drugs available for asthma treatment in the first decades of the 20th century
(sympathomimetic agents such as oral ephedrine, intravenous adrenaline, or inhaled …

Advances and highlights in asthma in 2021

I Agache, I Eguiluz‐Gracia, C Cojanu, A Laculiceanu… - Allergy, 2021 - Wiley Online Library
Last year brought a significant advance in asthma management, unyielding to the pressure
of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell …

Once-daily, single-inhaler mometasone–indacaterol–glycopyrronium versus mometasone–indacaterol or twice-daily fluticasone–salmeterol in patients with …

HAM Kerstjens, J Maspero, KR Chapman… - The Lancet …, 2020 - thelancet.com
Background Patients with asthma who are inadequately controlled on inhaled corticosteroid–
long-acting β 2-adrenoceptor agonist (ICS–LABA) combinations might benefit from the …

S2k-Leitlinie zur fachärztlichen Diagnostik und Therapie von Asthma 2023

M Lommatzsch, CP Criée, CCM de Jong… - …, 2023 - thieme-connect.com
Das Management von Asthma hat sich in den letzten Jahrzehnten fundamental gewandelt.
Die vorliegende Leitlinie zur Diagnostik und Therapie von Asthma wurde für pneumologisch …

A practical guideline of genomics-driven drug discovery in the era of global biobank meta-analysis

S Namba, T Konuma, KH Wu, W Zhou, Y Okada - Cell Genomics, 2022 - cell.com
Genomics-driven drug discovery is indispensable for accelerating the development of novel
therapeutic targets. However, the drug discovery framework based on evidence from …

Corticosteroid resistance in asthma: Cellular and molecular mechanisms

G Caramori, F Nucera, S Mumby, FL Bello… - Molecular aspects of …, 2022 - Elsevier
Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …

Advances in asthma: New understandings of asthma's natural history, risk factors, underlying mechanisms, and clinical management

RL Miller, MH Grayson, K Strothman - Journal of Allergy and Clinical …, 2021 - Elsevier
The last 2 years yielded a proliferation of high-quality asthma research. These include new
understandings of the incidence and natural history of asthma, findings on the effects of …

Indacaterol, glycopyrronium, and mometasone: pharmacological interaction and anti-inflammatory profile in hyperresponsive airways

P Rogliani, BL Ritondo, F Facciolo, MG Matera… - Pharmacological …, 2021 - Elsevier
Abstract LABA/ICS and LABA/LAMA/ICS combinations elicit beneficial effects in asthma.
Specific evidence concerning the impact of combining indacaterol acetate (IND) …

A review of the unique drug development strategy of indacaterol acetate/glycopyrronium bromide/mometasone furoate: a first-in-class, once-daily, single-inhaler, fixed …

D Brittain, P D'Andrea, E Gruen, M Hosoe, D Jain… - Advances in …, 2022 - Springer
A novel, once-daily (od), fixed-dose combination (FDC) of indacaterol acetate (IND),
glycopyrronium bromide (GLY), and mometasone furoate (MF), delivered by the inhaler …

[HTML][HTML] Impact of COVID-19 measures on exacerbation rates and healthcare visits in US asthma patients

H Karcher, M Schoenberger, T Rayban… - Allergy and Asthma …, 2023 - ncbi.nlm.nih.gov
Objective: To compare exacerbation rates and healthcare resource utilization (HCRU) in
real-world patients in the United States who had moderate-to-severe asthma on medium-or …