[HTML][HTML] The energy balance model of obesity: beyond calories in, calories out
ABSTRACT A recent Perspective article described the “carbohydrate-insulin model (CIM)” of
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …
[HTML][HTML] Assessment of insulin secretion and insulin resistance in human
SY Park, JF Gautier, S Chon - Diabetes & metabolism …, 2021 - synapse.koreamed.org
The impaired insulin secretion and increased insulin resistance (or decreased insulin
sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is …
sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is …
What a difference a hydroxyl makes: mutant IDH,(R)-2-hydroxyglutarate, and cancer
JA Losman, WG Kaelin - Genes & development, 2013 - genesdev.cshlp.org
Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
[HTML][HTML] Metabolic signaling in fuel-induced insulin secretion
M Prentki, FM Matschinsky, SRM Madiraju - Cell metabolism, 2013 - cell.com
The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …
according to the needs of the organism. Altered insulin secretion is linked to various …
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
H Khodabandehloo, S Gorgani-Firuzjaee… - Translational …, 2016 - Elsevier
Obesity is a major public health problem worldwide, and it is associated with an increased
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …
[HTML][HTML] Nutrient regulation of insulin secretion and action
Pancreatic β-cell function is of critical importance in the regulation of fuel homoeostasis, and
metabolic dysregulation is a hallmark of diabetes mellitus (DM). The β-cell is an intricately …
metabolic dysregulation is a hallmark of diabetes mellitus (DM). The β-cell is an intricately …
[HTML][HTML] Insulin granule biogenesis and exocytosis
M Omar-Hmeadi, O Idevall-Hagren - Cellular and Molecular Life Sciences, 2021 - Springer
Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone
stimulates glucose uptake and suppresses glucose production. Defects in both the …
stimulates glucose uptake and suppresses glucose production. Defects in both the …
[HTML][HTML] Low glycemic index rice—a desired trait in starchy staples
AK Jukanti, PA Pautong, Q Liu… - Trends in Food Science & …, 2020 - Elsevier
Background The global shift in food consumption patterns accompanied by a sedentary
lifestyle has been driving the upsurge of non-communicable diseases, projected to remain …
lifestyle has been driving the upsurge of non-communicable diseases, projected to remain …
[HTML][HTML] An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets
RM Elgamal, P Kudtarkar, RL Melton, HM Mummey… - Diabetes, 2023 - Am Diabetes Assoc
Pancreatic islets consist of multiple cell types that produce hormones required for glucose
homeostasis, and islet dysfunction is a major factor in type 1 and type 2 diabetes. Numerous …
homeostasis, and islet dysfunction is a major factor in type 1 and type 2 diabetes. Numerous …
Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and …
PA Harnedy-Rothwell, CM McLaughlin… - Food Research …, 2020 - Elsevier
Twenty-two novel dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides (with IC 50 values<
200 µM) and fifteen novel insulinotropic peptides were identified in a boarfish protein …
200 µM) and fifteen novel insulinotropic peptides were identified in a boarfish protein …